Год выпуска: 2013 Автор: Olayinka Oyewale Ajani Издательство: LAP Lambert Academic Publishing Страниц: 272 ISBN: 9783659359361
Описание
The reaction of a–toluenesulphonyl chloride with various readily available amino acids in basic medium afforded a–toluenesulphonamides (1a-k) which were amidated with diethyl amine to obtain new N,N-diethylalkanamido sulphonamide derivatives (2a-k). The electrophilic addition of p-toluenesulphonyl chloride with various amino acids' nitrogen gave p-tolylsulphonamide derivatives (4a-k) which upon further reaction with diethylamine afforded N,N-diethylamido substituted sulphonamide moieties (5a-k). Sulphonylation of the amino acids with benzenesulphonyl chloride yielded benzenesulphonamides (7a-k) which were amidated to afford N,N-diethylamido benzenesulphonamide derivatives, (8a-k). The chemical structures were confirmed by elemental analysis and spectroscopic techniques which involved FT-IR, Mass Spectra, 1H- and 13C-NMR. The antimicrobial properties of the synthesized sulphonamides (fifty five compounds) were determined on Staphylococcus aureus and Escherichia coli using agar...
