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Studies Towards the Synthesis of (–)-Ebelactone-A and (–)-Maurenone



Год выпуска: 2012
Автор: Ravindar Kontham and Jhillu Singh Yadav
Издательство: LAP Lambert Academic Publishing
Страниц: 164
ISBN: 9783848449583
Описание
This monograph features the studies directed towards the total synthesis of architecturally and biologically interesting polypropionate natural products (-)-Ebelactone-A and (-)-Maurenone utilizing desymmetrization as a key strategy. (–)-Ebelactone A, show structural characteristics in common with macrolide antibiotics. Ebelactones act as potent inhibitors of esterase’s, lipases and N-formylmethionine amino peptidases, and they have shown to produce enhance immune responses. They are also reported to inhibit cutinases produced by fungal pathogens. Novel biological activity combined with unique and challenging structure of Ebelactone, made this compound an exciting target for the total synthesis. Secondly, this book described an efficient synthetic protocol for polypropionate natural product (-)-Maurenone, which was isolated by Faulkner et al. in 1986 from specimens of the pulmonate mollusc Siphonaria maura. This monograph is unique in dealing with many interesting synthetic protocols...


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