Embryonic development of dopamine and serotonin in epilepsy
Год выпуска: 2013 Автор: Prem Prakash Tripathi Издательство: LAP Lambert Academic Publishing Страниц: 104 ISBN: 9783659354922 Описание The embryonic development of the Central Nervous System (CNS) requires an orchestrated series of events tightly regulating the patterning and regionalization of the neural tube, as well as the proliferation and differentiation of distinct neuronal populations. All these events are controlled by cascades of activation of transcription factors that regulate the expression of specific subsets of genes in restricted regions and neuronal populations of the developing CNS. Among these transcription factors, homeobox-containing proteins play a crucial role, and altered expression of these factors can impact embryonic and adult CNS functions. In particular, homeobox-containing genes have been described to crucially regulate differentiation of dopaminergic and serotonergic neurons during brain development. Classical pharmacological studies clearly showed that both dopamine and serotonin markedly regulate seizure susceptibility through specific receptor pathways. Our recent studies, performed...
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Люба, 25.09 Юля, огромное Вам спасибо за работу! Мне ОЧЕНЬ понравилось. Здорово, что вы есть. О результате сообщу. Всего доброго! Удачи!