Elucidating the role of MKK4 in neuronal apoptosis Год выпуска: 2010Автор: Auriane DestrumentИздательство: LAP Lambert Academic PublishingСтраниц: 144ISBN: 9783838336862Описание Brain injury and neurological conditions are often associated with the excessive loss of neurones through apoptosis. In the brain, apoptosis is triggered by the activation of the c-Jun N-terminal protein kinase (JNK) signalling pathway by two mitogen-activated protein kinases (MAPKs): MKK4 and MKK7. While both proteins activate JNK in response to various extracellular stimuli, the biological functions of MKK4 and MKK7 in neuronal cell death remain to be identified. To advance our knowledge, I have developed two novel models of neuronal apoptosis using primary cultures of cortical neurones (MECN) and cerebellar granule neurones (CGN) in which MKK4 expression can be deleted. The absence of MKK4 significantly impedes stress-induced caspase-3 activation in both cell types and partially protects neurones against stress-induced death and apoptosis. Furthermore, the loss of MKK4 leads to the inhibition of JNK3 activation following stress, and causes a marked decrease in...
Похожие книги
Association of Academies of Sciences in Asia. Towards a Sustainable Asia: The Cultural Perspectives. – М.: , 2012. – 120 с. Twentieth Century Fund/Century Foundation, Century Foundation Task Force on the Future of Unions. What's Next for Organized Labor?: Report of the Century Foundation Task Force on the Future of Unions. – М.: , 0. – 0 с. K. Alec Chrystal, Rupert Pennant-Rea, British Association for the Advancement of Science Section F. Public Choice Analysis of Economic Policy (British Association for the Advancement of Science Books). – М.: , 0. – 0 с. Frank Ackerman, David Kiron, Neva R. Goodwin, Jonathan M. Harris, Kevin P. Gallagher, Program for the Study of Sustainable Change and Development. Human Well-Being and Economic Goals (Frontier Issues in Economic Thought, Vol 3). – М.: , 0. – 0 с. Ian R. Bowler, C. R. Bryant, C. Cocklin, Chris Cocklin, International Geographical Union Commission on the Sustainability of R. The Sustainability of Rural Systems - Geographical Interpretations. – М.: , 0. – 0 с. Peg Pickering, Jonathan How to Make the Most of Your Workday Clark. How to Make the Most of Your Workday. – М.: , 0. – 0 с. The Editors of VGM Career Books. McGraw-Hill's Big Red Book of Resumes. – М.: , 0. – 0 с. The Editors of Career Press, Career Press Inc. Resumes! Resumes! Resumes!: Top Career Experts Show You the Job-Landing Resumes That Sold Them. – М.: , 0. – 0 с. Susan A. Resetar, Frank A. Camm, Jeffrey A. Drezner, Rand Corporation, United States Dept. of Defense Office of the Secretary of Defense, National Defense Research Institute. Environmental Management in Design: Designs from Volvo and Hewlett-Packard for the Department of Defense. – М.: , 0. – 0 с. Dag Harald Claes, Dag Harald Claes ARENA: Advanced Research on the Europeanisation of the Nation-State. The Politics of Oil-Producer Cooperation. – М.: , 0. – 0 с. International Conference on the Conduct of Monetary Policy, Jin-Lung Lin, Jia-Dong Shea, Chung-Shu Wu, Gerald P., Jr. Dwyer, Gerald P. Dwyer. Monetary Policy and Taiwan's Economy (Academia Studies in Asian Economies Series). – М.: , 0. – 0 с. State of the Art of Research in International Marketing Conference. Handbook of Research in International Marketing. – М.: , 2003. – 0 с. Committee on the Significance of International Transport of Air Pollutants, National Research Counci. Global Sources of Local Pollution: An Assessment of Long-Range Transport of Key Air Pollutants to and from the United States. – М.: , 2010. – 225 с. Committee on Forefronts of Science at the Interface of Physical and Life Sciences, National Research. Research at the Intersection of the Physical and Life Sciences. – М.: , 2010. – 102 с. The Run of the. The Run of the House. – М.: , 1993. – 0 с. The Centre for Public Law at the University of Cambridge. Constitutional Reform in the United Kingdom. – М.: , 2011. – 144 с. The Editors of Hamptons Cottages and Gardens. Hamptons Havens : The Best of Hamptons Cottages and Gardens. – М.: Bulfinch, 2005. – 192 с. Образцы работ
Задайте свой вопрос по вашей теме
Контакты
Поделиться
Мы в социальных сетях
Реклама
Отзывы
Ангелина, 28.01 Предзащиту прошла!) ура! Сказали там исправить некоторые вещи! Но я попробую сама! Вроде ничего серьезного. Сейчас отправила преподу на проверку! Сказал вечером проверит. Спасибо что успели переделать!
