Effects of Demethylation on the Expression of Foxp3 in T-reg Cells Год выпуска: 2014Автор: Edmund YaoИздательство: LAP Lambert Academic PublishingСтраниц: 92ISBN: 9783659495090Описание CD4+Foxp3+ regulatory T cells (TREG) are pivotal in the maintenance of immune tolerance to self-antigens and act as regulators of autoimmune reactions. There are two subsets of TREG: naturally occurring (nTREG) which develop in the thymus and inducible (iTREG) which are generated from conventional Foxp3- effector T cells (TCONV) in the periphery or in vitro. While both subsets require Foxp3 expression to function, iTREG cells gradually downregulate Foxp3 in vitro and lose their suppressive capabilities. In contrast, nTREG cells show constitutive Foxp3 expression and demonstrate stable suppressive function in vitro. Recent studies reveal a region of the Foxp3 locus that is differentially methylated between nTREG and iTREG. The methylation-sensitive region, known as the TREG-specific demethylated region (TSDR), is completely unmethylated in nTREG, partially methylated in iTREG, and heavily methylated in TCONV, suggesting that differential methylation patterns of the TSDR may account for...
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Наталья, 23.05 Спасибо огромное Марине!!! Я защитилась на \хорошо\, не ответила на один вопрос (по поводу закона). Более трети человек из группы гос.аттестационная комиссия завернула из-за плохого содержания работы. Содержание моего диплома им очень понравилось! Всем рекомендую студенточку :)
