Год выпуска: 2013 Автор: Ashok Palaniappan Издательство: LAP Lambert Academic Publishing Страниц: 148 ISBN: 9783659503887
Описание
Potassium (K+) channels are tetrameric membrane proteins that play a critical role in diverse life-sustaining processes, e.g., the action potential. Their clinical significance is underscored by the observation that they are likely the founding members of the voltage-gated ion channel superfamily that includes sodium and calcium channels. The research aimed to address the gaps in our current understanding of K+ channel biology. The themes were as follows: classification of genome-complement of K+ channels; analysis of intrasubunit heterodomain co-evolution; sequence determinants of subfamily-specific channel phenotypes; and finally, structure-function-evolution relationships. The highlight was the detection of deep co-evolution between the permeation pathway of K+ channels and the corresponding channel regulatory domain. Reconstruction of the ancestral sequence of each subfamily yielded insights into the mutations that formed the biochemical basis for the range of functional...
