Год выпуска: 2011 Автор: Martina Krautwald Издательство: LAP Lambert Academic Publishing Страниц: 84 ISBN: 9783844316186
Описание
Advanced glycation end products (AGEs) play a major role in age-related diseases like Alzheimer''s disease. 1,2-dicarbonyl compounds, such as glyoxal (GO) and methylglyoxal (MGO), are involved in the formation of these AGEs. Thus, it was hypothesised that the progression of Alzheimer''s disease can be slowed down by lowering the concentration of 1,2-dicarbonyl compounds, which will consequently lead to a decrease in AGE formation. Therefore, the aim of this work was to establish an HPLC-method for the detection of glyoxal and methylglyoxal from cultured cells in order to determine the potential of different agents to lower the concentration of these 1,2-dicarbonyl compounds. Furthermore, it was assessed whether ALT-711 (Alagebrium), an AGE lowering agent, is an inhibitor of the enzyme thiamine diphosphokinase, due to its structural homology to the enzyme''s natural substrate thiamine. This enzyme is responsible for the formation of thiamine diphosphate, the co-factor of the enzyme...
Спасибо за столь доброе отношение к нам простым смертным :-), горе-студентам или, еще можно сказать- вечным студентам, которые не помнят, когда начали это свое высшее, но уже до зеленой тоски опостылевшее, образование.