Год выпуска: 2012 Автор: Puthoori Haripriya,T.E.G.K. Murthy and Atul Kaushik Издательство: LAP Lambert Academic Publishing Страниц: 148 ISBN: 9783659268595
Описание
In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood. This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease. Hence control of blood cholesterol levels is very much important to reduce the risk of CVD. In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution. This reduces the levels of LDL and triglycerides in the blood to a major extent. On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release. Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL,...
