Год выпуска: 2012 Автор: Balamurugan Pandiyan Издательство: LAP Lambert Academic Publishing Страниц: 160 ISBN: 9783659197390
Описание
The purpose of modeling the negative feedback control mechanism of the hypothalamus-pituitary- thyroid (HPT) axis in autoimmune thyroiditis is to describe the clinical course of euthyroidism, subclinical hypothyroidism and overt hypothyroidism for patients. Thyroid hormone unbound thyroxine (FT4) levels are controlled by negative feedback control through thyroid stimulating hormone(TSH). Autoimmune thyroiditis is a disease in which the thyroid-infiltrating lymphocytes attack autoantigens in follicle cells, destroying them over a long time. To describe the operation of the feedback control, we developed a deterministic mathematical model involving four clinical variables - TSH, FT4, anti-thyroid antibodies and the thyroid gland’s functional size. The problem of two different time scales for circulating hormones and thyroid damage is addressed using singular perturbation theory. Analysis of the mathematical model establishes stability and conditions under which the diseased state can...
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