Age-adjusted cancer therapy based on the reduced malignancy in the old Год выпуска: 2009Автор: Tatiana Kaptzan,Judith Leibovici and Ehud SkutelskyИздательство: LAP Lambert Academic PublishingСтраниц: 180ISBN: 9783838334936Описание In view of the constant increase in the aged population with its high cancer incidence, age- adjusted cancer therapy should constitute an urgent target. Although cancer incidence rises with age, paradoxically, growth rate and metastasis often proceed at a slower rate in the aged. Determining the mechanisms underlying this reduced tumor progression in the old showed increased apoptosis of tumor cells, decreased angiogenesis and changes in immune response. The authors postulated that it may be possible to design rational age-adjusted treatment modalities based on the mechanisms of the reduced tumor progression rate in the aged. They showed that three treatment modalities based on these mechanisms (using drugs inducing apoptotic cell death, immunomodulators and anti-angiogenic therapy) display an age-related differential effect on two experimental tumors. Remarkably, these treatments were generally more efficient against tumors growing in old than against those developing in young...
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Ирина, 30.03 Юлия, добрый вечер! Я сдала диплом на 5. Спасибо Вам! Конечно все выводы и заключения наши были исправленны! Однако, хочу сказать, что мы двоем защищались у этого научного руководителя и все было достойно! Я не верила, что в МГУ серьезные требования!!! Ан нет!!! Всего Вам доброго! Все-равно спасибо!!!!
