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DESIGN OF OSMOTIC CONTROLLED DRUG DELIVERY SYSTEM



Год выпуска: 2010
Автор: Ambikanandan Misra and Pritam D. Kanagale
Издательство: LAP Lambert Academic Publishing
Страниц: 232
ISBN: 9783838392271
Описание
Osmotic systems, one of the oral dosage form utilize the principles of osmotic pressure for the delivery of drugs. Drug release from these systems is independent of pH and other physiological parameters and it is also possible to modulate the release characteristics by optimizing the properties of drug and system. The aim of present research was to design and optimize the three novel osmotic drug delivery systems viz. Swellable Porous Osmotic System (SPOP), Monolithic Osmotic Tablet System (MOTS) & Controlled Porosity Osmotic System (CPOP) for water soluble and low water soluble drugs and compare principle and methodology of CR design. Extended release formulations of Venlafaxine HCl and Glipizide were developed based on SPOP technology. Extended release formulations of Metoprolol Tartrate and Nifedipine were developed based on MOTS technology. Extended release formulations of Oxybutynin chloride and Atenolol were developed based on CPOP technology. Based on the present work it...


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