Год выпуска: 2010 Автор: Swarupananda Mukherjee Издательство: LAP Lambert Academic Publishing Страниц: 112 ISBN: 9783843368247
Описание
The present investigation involves development of a CR Nifedipine microparticulate system utilizing starch acetate as the rate controlling polymer. SA was manufactured in house form native starches and characterization for degree of substitution (dS) and acetyl content among other parameters. An emulsification solvent evaporation technique was followed to develop microparticles of varying drug- polymer ratio''s with triethyl citrate plasticizers at different levels. The prepared microparticles were subjected to standard evaluation such as yield, particle size, surface topography, drug content and in vitro dissolution studies.The development formulations were subsequently optimized through a simplex lattice mixture design to predict the optimum formulations matching the target official release profiles. It was found that two blend of development formulations, namely F1: F5 (0.822:0.1780) and F5: F13 (0.041:0.959) could closely resemble official specification and hence...
