Год выпуска: 2012 Автор: Anila Saeed,Afshan Kaleem and Hania Ramzan Издательство: LAP Lambert Academic Publishing Страниц: 88 ISBN: 9783659126147
Описание
Bioinformatics is a helpful tool to experimental studies. It is less time consuming and may provide a platform for experimental work. Post translational modification is investigated in silico, with the help of the bioinformatics tool MAPRes. This tool mines association pattern around a modified residue. In this work association rules were mined around methylated Lys/Arg residues in protein. These rules show highest preference for Gly in modified protein Arg and Ser and Gln in modified protein Lys. 75% data support the preference of Gly in methylated Arg with 100% confidence level. 25% data support the preference of Ser and Gln in methylated Lys with 100% confidence level. The comparison of MAPRes analysis results for predicted Lys and predicted Arg substrate sites with those of MeMo, MASA and BPB-MMS prediction methods show a high conformity level, ranging from 13% to 72%. This high rate of conformity points to the accuracy of the algorithm and the technique of data mining applied in...
