Год выпуска: 2011 Автор: Micaela Castellino Издательство: LAP Lambert Academic Publishing Страниц: 196 ISBN: 9783846530948
Описание
The study of cellular adhesion and growth on solid state substrates is a prerequisite for the evaluation of material bio-compatibility. The knowledge of the effects of topographical and chemical features of the surface on cell viability is pivotal for the development of cell-based bio-sensors, as the interface seriously influences the optical/electrical cellular signal transduction. In this book I present our contribution for the assessment of Nanocrystalline Diamond (NCD) bio-compatibility in terms of cellular adhesion and viability. Nanocrystalline diamond samples deposited on quartz substrates and a reference homoepitaxial CVD diamond sample, were used as transparent substrates to plate cultured primary neuroendocrine cells and GT1-7 clonal cell line. Surface topography at the nanoscale by AFM, composition by XPS and electro/optical features were evaluated to qualify the sample surfaces after plasma hydrogenation, different exposures to UV and wet oxidation. In order to...
