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Molecular and Clinical Impact of BCR-ABL Fusion Transcripts in CML



Год выпуска: 2014
Автор: Abdel Rahim Muddathir,Imad Fadl-Elmula and Anwaar Kordofani
Издательство: Scholars' Press
Страниц: 176
ISBN: 9783639516210
Описание
In Sudan, CML is the most common cancer among males and the second most common cancer among females. Differences in the site of BCR breakpoint and the types of BCR/ABL transcripts suggest that subtypes of CML may have different prognosis and clinical course. This book therefore, aimed to determine the common frequencies of BCR/ABL fusion transcripts, and to quantify the BCR/ABL fusion transcripts and to correlate the obtained findings with hematological and clinical course findings of the disease at diagnosis. Our finding in this book showed distinct genetic profile of CML in Sudan in contrast with what have been reported in other population including those of Europe. This has been demonstrated in different frequencies of BCR-ABL rearrangements suggesting that the transcripts frequencies among Sudanese patients may be due to the ethnically different target populations. The results may explain also the distinct CML clinical course observed in Sudanese patients compared with the...


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SweetGerl, 27.01
Защитилась вчера на 4...Спасибо Вам ;)