Год выпуска: 2012 Автор: Zena A. Abdul Hameed Al-Mudaris,Amin Abdul Majid and Sedigheh Mehrabian Издательство: LAP Lambert Academic Publishing Страниц: 164 ISBN: 9783659167713
Описание
Benzyl-o-vanillin and benzimidazole nucleus serves as an important pharmacophore in drug discovery as it have a significant medicinal importance. Thus we explored the anticancer activity of three relative compounds and found their structure activity relationship compare with 2-benzyloxy-3-methoxybenzaldehyde main structure. According to the cytotoxicity analysis, they induce cell death of leukemic cell line through DNA fragmentation. DNA binding studies reveals that the DNA binding occurs through groove region. The higher mutagenicity might cause DNA mutation through interaction with the guanines while the lack of significant mutagenic activity suggests that the compound may target mainly the AT rich sequences of the nucleic acid. Hence, the present study provides a new insight of these novel (2-benzyloxy-3-methoxyphenyl) derivatives serving as a potential therapeutic agent against leukemia. This work should help shed some light on these exciting compounds and their SAR results, and...
