Год выпуска: 2013 Автор: Abhijit Bandyopadhyay Издательство: LAP Lambert Academic Publishing Страниц: 168 ISBN: 9783659445491
Описание
Beside its toxic side effects on vital proliferating tissues of the patient, chemotherapy is still a treatment of choice for certain forms of human malignancy. Though most anti-cancer drugs are known to exert their cell killing effect through various intracellular pathways, including their interference with the DNA replication, many anticancer agents has not, in general, been chosen for therapy after a thorough evaluation of their cytotoxic effect on chromosomes of proliferating body cells. This work has been designed to provide an understanding of the nature and extent of cytotoxicity of a widely used second generation platinated anticancer agent, Carboplatin on bone marrow cells of both non tumor and tumor bearing mice and its possible modulation by three diverse agents viz. Glutathione (chemo-preventive agent), Mitomycin C (anticancer antibiotic) and Amphotericin B (anti-fungal agent). Tumor bearing mice were included in the present program to find out whether tumor load has any...
