Год выпуска: 2010 Автор: Theis Reenberg Издательство: LAP Lambert Academic Publishing Страниц: 144 ISBN: 9783838335940
Описание
The present thesis concerns the supramolecular recognition of mono- and disaccharides in water as well as an introduction to combinatorial chemistry utilizing encoded polymer beads. The thesis gives a short introduction to the literature regarding the recognition of carbohydrates via supramolecular chemistry and discusses the advantages and disadvantages of the different approaches. The synthesis of a peptide based bicyclic carbohydrate receptor has been developed utilizing a combination of solid-phase chemistry and chemistry in solution. The synthesis proceeded over 28 steps with a total yield of 6.4 %, equivalent to an average yield in excess of 90 % per step. The receptor contains a dodecapeptide connected via a naphthalene, and was designed to bind to carbohydrates through a combination of CH- interactions and hydrogen bonds. The final chapter describes the use of encoded polymer beads in combinatorial chemistry. The methodology was investigated with the aim of discovering new...
