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Metal complexes as antimicrobial agents and in biomimetics


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Год выпуска: 2010
Автор: Anil Damodar Naik
Издательство: LAP Lambert Academic Publishing
Страниц: 152
ISBN: 9783838330396
Описание
 The metal-sulfur entities perform an unprecedented role in biological systems. Comprehension of their diversity in structure and function is indispensable in the realm of drug design and biomimetics. The present text embodies an interdisciplinary approach to the design, synthesis and applications of some metal complexes. It offers an overview of synthesis of binucleating ‘Robson-type'' SNONS donor ligands, their transition metal complexes and a descriptive analytical, spectroscopic, magnetic, electrochemical characterizations. These novel molecules were capitalized for in vitro antimicrobial activities due to their topological resemblance to some known pharmacophores. Among the designed sulfur donor ligands, thiohydrazones and thiocarbohydrazones show exceptional fungistatic potentials. Also at appropriate places in the text the unique properties of these ‘synthetic analogs'' were compared with that of a known metalloprotein. The meticulous organic synthesis, the bifunctionalities...

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