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Molecularly Imprinted Receptor Targeting Lung Cancer Biomarker



Год выпуска: 2014
Автор: Abed Abdel Qader
Издательство: LAP Lambert Academic Publishing
Страниц: 168
ISBN: 9783659570155
Описание
The early diagnosis of biomarker is crucial for patient survival and successful prognosis of the disease, and for this reason sensitive and specific methods are required for early cancer diagnosis. However, common techniques for separation and concentrating biomarker are not optimal from the viewpoints of sensitivity and selectivity because analyzing these biomarkers from a small amount of serum is difficult due to the complexity of the sample and low levels of these biomarkers. Peptide imprinted polymers were developed for detection of progastrin releasing peptide (ProGRP); a low abundant blood based biomarker for small cell lung cancer. Peptide imprinted polymers with the best affinity characteristics were first identified from a 96-polymer combinatorial libraries. The effects of monomers, crosslinker, porogen, and template on adsorption capacity and selectivity for nonapeptide sequence NLLGLIEAK resulting from tryptic digestion were investigated and optimized. Ultimately, a solid...


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Слияния и поглощения Мировая и Российская практика
Мировая экономика
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Natalia
Ого! Даже не ожидала такой скорости ) Спасибо)