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Novel Steroidal Breast Cancer Drugs


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Год выпуска: 2012
Автор: Gamal A. Elmegeed,Wagdy K. B. Khalil and Ghada H. Elsayed
Издательство: LAP Lambert Academic Publishing
Страниц: 144
ISBN: 9783659137242
Описание
 Breast cancer is reported to be one of the commonest cancers and the most common cause of cancer death among women worldwide, and especially young women in the developing world. Anti-cancer agents, which combine two biologically active compounds in one such as hybrid steroids attain both hormone and cytotoxic effects on cancer cells. The aim of the present study is to synthesize and evaluate new potential chemotherapeutic anti-breast cancer agents. Several pyridazino-, pyrimido-, quinazolo-, oxirano- and thiazolo-steroid derivatives were synthesized. The most structurally promising, compounds 8, 12, 17, 20, 22c, 24c, 30a and 30b, were investigated individually as anti-breast cancer agents against human breast cancer cells (MCF-7) using sulforhodamine B (SRB) assay. Some compounds exhibited more inhibitory influence on MCF-7 growth than the reference drug doxorubicin (Dox). Also, the present study showed that all the tested steroid derivatives exhibited significant depletion with...

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