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Antimicrobial metabolites from Arctic/sub-Arctic marine invertebrates



Год выпуска: 2011
Автор: Margey Tadesse
Издательство: LAP Lambert Academic Publishing
Страниц: 68
ISBN: 9783838380438
Описание
Infectious diseases are a leading cause of death world-wide and there is a growing need for new anti-infective agents to combat multi-resistant strains of bacteria and fungi. In the present thesis, an investigation into the antimicrobial metabolites of Arctic and sub-Arctic marine invertebrate species is presented. Extracts of sponge, ascidian, coral and bryozoan species were pre-fractionated by solid phase extraction (SPE) and purified by reverse-phase high-performance liquid chromatography (RP-HPLC). Active metabolites were characterized by electrospray ionization mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR) techniques. The work resulted in the isolation and characterization of a number of new metabolites including the novel synoxazolidinones A, B and C, which exhibited antimicrobial and anticancer activities. In addition, the thesis provides background information on natural product research and current antimicrobial investigations of marine invertebrate species....


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