Год выпуска: 2011 Автор: Amin Abdou Seleem Mohamed Издательство: LAP Lambert Academic Publishing Страниц: 160 ISBN: 9783845412023
Описание
The present study was designed and carried out to investigate the role of connective tissue growth factor (CTGF) during eye development of CD1 mice at pre- and postnatal stage by using different technique as Real time PCr and Immunohistochemistry In conclusion CTGF is essential for life and absence of this gene lead to the death, Knockout homozygous CTGF -/- severe from a lot of abnormalties during prenatal stages until death. The over-expression CTGF transgenic mice with high concentration in line 6 showed a disappearance of the ciliary body processes, while the moderate over-expression CTGF of line 5 and low over-expression of line 1 showed abnormalities in the trabecular meshwork on the levels of immunohistochemistry that was accompanied with an increase in intraocular pressure and degeneration of optic nerve axons. So, we suggest that the over-expression of CTGF can cause the primary open angle glaucoma. The mice from line 1 and 5 can use as a model for primary open angle...
