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Human Fidgetin and Its Functions in Mitosis and Cell Migration



Год выпуска: 2012
Автор: Suranjana Mukherjee and David Sharp
Издательство: LAP Lambert Academic Publishing
Страниц: 96
ISBN: 9783659212888
Описание
Microtubule is an essential component of the cytoskeleton required for several important cellular processes such as cell division, cellular morphogenesis and migration. In cells, functions of microtubules are tightly regulated by additional microtubule-associated proteins called MAPs. Fidgetin is a microtubule-associated protein, which influences several microtubule based cellular processes by regulating microtubule dynamics. Fidgetin is a microtubule severing and depolymerizing enzyme and possibility by utilizing these properties it regulates mitosis and cellular migration. Both of these processes are extremely important during cell proliferation and tissue morphogenesis. Defects in these processes may lead to malignant transformation and developmental defects including neurodegenerative disease, as the formation of neuronal processe is in many ways a modified form of cell migration. Notably, Fidgetin mutation causes developmental and behavioral defects in mice. This study might lead...


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Ирина
Марина Михайловна, хочу выразить вам огромную благодарность за дипломную работу после вашего сопровождения. Моему профессору она очень понравилась, принял ее почти в таком виде как вы советовали, с незначительным редактированием содержания, которое я сделала сама.