Molecular Optimization of Calcineurin Inhibitors for Prion Disease
Год выпуска: 2012 Автор: Saumya Patel,S.Prasanth Kumar and Yogesh T. Jasrai Издательство: LAP Lambert Academic Publishing Страниц: 80 ISBN: 9783659158957 Описание This study mainly emphasizes on pharmacophore features available in the immunosuppressant drugs, especially Calcineurin inhibitors for human prion diseases. The structural and functional properties of FK506/Tacrolimus - a drug used for treatment of human prion diseases were enhanced through pharmacophore-assisted molecular optimization approach. Important pharmacophore features responsible for interaction with active site and intramolecular structural stability were elucidated.
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Алексей Проконсультировали оперативно .Доволен качеством .Спасибо!