Mechanisms of Leptin in Breast Cancer Development and Progression Год выпуска: 2010Автор: Candida Perera and Ignacio CamarilloИздательство: LAP Lambert Academic PublishingСтраниц: 128ISBN: 9783838373331Описание Obesity is a recently established risk factor for breast cancer. A characteristic of obesity is elevated circulating levels of adipocyte-derived hormone leptin. Evidence indicates leptin plays an important role in breast cancer development and progression; however the mechanisms involved are poorly understood. Towards better defining the role of leptin in breast cancer, herein we describe the identification of leptin-regulated genes and proteins in hormone responsive MCF-7 human breast cancer cells. Leptin significantly increased the proliferation and protein secretion in MCF-7 cells. The effect of leptin in modulating the extracellular environment and inhibiting apoptosis was also determined. These data suggest leptin regulates mammary tumor cell behavior through multiple mechanisms. In addition to regulating mitogenic cell signaling pathways, leptin influences mammary tumor cell growth by regulating apoptosis, cell cycle, secretion of autocrine/ paracrine factors...
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Юлия, 03.03 Добрый день, Юля! Я сегодня защитила диплом на отлично :-) Хотела сказать Вам ОГРОМНОЕ спасибо за помощь! Вы мне помогали с написанием курсовых работ на протяжении всего срока моего обучения. Без Вашего участия мне было бы в сто раз труднее, ведь я работаю и времени на написание курсовых и диплома всегда катастрофически не хватало. Так что в том, что я закончила этот университет есть большая доля и вашего участия. Ещё раз огромное Вам за это спасибо! Будьте счастливы и удачи Вам! При случае, буду рекомендовать Вас своим знакомым, кому понадобятся подобные услуги ;-)
