Год выпуска: 2010 Автор: Diana Hazai Издательство: LAP Lambert Academic Publishing Страниц: 76 ISBN: 9783838396231
Описание
Duchenne muscular dystrophy (DMD)is one of the most common, severe human disease. Mutations in the DMD gene are responsible for the disorder. Due to the mutations, dystrophin proteins are not expressed or expressed in functionally impaired form. The dystrophins are members of the dystrophin-associated protein complex (DAPC)located in the sarcolemma in the striated muscle. The DAPC links the extracellular matrix to the actin-based cytoskeleton and anchors signalling molecules. DAPC proteins are also localized in neurons and glia cells within the central nervous system and they interact with each other building up different types of DAPCs. Finding out the localization, colocalization of the DAPC proteins and the construction of the DAPC within the brain was the aim of the research and we also analyzed what kind of changes might occur with DAPC proteins without dystrophin in dystrophin- deficient mice. There are several DAPC protein variants located around the...
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