Год выпуска: 2011 Автор: Stephanie Jo Издательство: LAP Lambert Academic Publishing Страниц: 124 ISBN: 9783844383706
Описание
Disruptor of telomeric silencing 1-like (Dot1l) is a histone 3 lysine 79 methyltransferase. Constitutive Dot1l knockout mice studies show that Dot1l is essential for prenatal development and hematopoiesis. Dot1l also interacts with fusion partners of Mixed Lineage Leukemia (MLL) gene, which is commonly translocated in human leukemia. However, the requirement of Dot1l in postnatal hematopoiesis and leukemogenesis of MLL translocation proteins have not been conclusively shown. With conditional Dot1l knockout mouse model, we examined the consequences of Dot1l loss in postnatal hematopoiesis and MLL translocation leukemia. Deletion of Dot1l led to failure of hematopoietic homeostasis, and Dot1l- deficient cells minimally reconstituted recipient bone marrow. In addition, MLL-AF9 cells required Dot1l for oncogenic transformation, while cells with other leukemic oncogenes such as Hoxa9/Meis1 and E2A- HLF did not. Furthermore, loss of Dot1l affected histone...
Здравствуйте, Марина. 20 мая у нас была защита дипломов. Мы с Таней защитились. У меня 5, у неё 4. Все довольны, спасибо Вам большое за помощь. Если вдруг надумаем учиться дальше, обязательно к Вам обратимся. До свидания, спасибо за плодотворное сотрудничество.