Год выпуска: 2012 Автор: Kanny Diallo Издательство: LAP Lambert Academic Publishing Страниц: 104 ISBN: 9783659289255
Описание
Macrophages are the first line of defense against microbial pathogens; they recognize microbial structures and products via surface receptors and intracellular antigen sensors. Engagement of surface receptors results in phagocytosis of the microbe into a specialized vacuole, the phagosome. Through a series of fusogenic events, the phagosome matures into a microbicidal phagolysosome that is highly acidic and contains a number of degradative enzymes and toxic molecules that cause destruction of the microbe. Salmonella typhimurium (S. typhimurium) and Legionella pneumophila (L. pneumophila) are two pathogenic Gram-negative bacteria that are able to block phagosome maturation. The hypothesis is that the macrophages’ response to these pathogens contains a common as well as a pathogen-specific response. Genome-wide transcription profiling approach was used to compare macrophage responses to phagocytosis of S. typhimurium or L. pneumophila at early time points, 2h and 4h post-infection. This...
