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USE OF HLA-B27PCR TECHNIQUE FOR DETECTION OF ANKYLOSING SPONDYLITIS


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Год выпуска: 2011
Автор: Anshul Shrivastava
Издательство: LAP Lambert Academic Publishing
Страниц: 76
ISBN: 9783844330649
Описание
 HLA-B27 is a class I surface antigen encoded by B locus in the Major Histocompatibility Complex (MHC) on the short (p) arm of chromosome no.6,presents microbial antigen to T cells. HLA B is a human gene that provides instruction for making a protein that plays a critical role in immune system.HLA-B27 is strongly associated with a certain set of autoimmune disease referred as the “Seronegative Spondyloarthropathies”, a group of disorders that include Ankylosing Spondylitis (AS) and other inflammatory joint diseases. It has been found that 90% of patients with this rheumatic disease have HLA- B27 antigen , compared with 10% of healthy controls. PCR for detection of HLA-B27 is extremely accurate and considered the standard method. The aim of this prospective study was to identify the positivity rate of HLA-B27 in different age group and sex of patients by using Sequence Specific Primer typing (SSP)-PCR approach in a selected population, suffering from Ankylosing...

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Тильда, 17.06
Получила. Спасибо за оперативность.