the role of cytokines on synaptic plasticity in the dentate gyrus Год выпуска: 2011Автор: Derval CumiskeyИздательство: LAP Lambert Academic PublishingСтраниц: 260ISBN: 9783844319941Описание Pro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer’s disease. Tumour necrosis factor-? (TNF-?) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF-? and IL-18 mediated inhibition of LTP. Initial experiments consolidate evidence on inducing LTP in the dentate gyrus of the hippocampus. Subsequent experiments consolidate evidence that TNF-? and IL-18 can impair LTP in the dentate gyrus.
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Мария, 26.12 Мариночка! Большое Вам спасибо, я защитилась с оценкой отлично. Мне очень понравилось с Вами работать!!! Буду рекомендовать другим студентам. С Уважением и большой признательностью. Еще раз спасибо!
