Год выпуска: 2011 Автор: Jayadeepa R.M Издательство: LAP Lambert Academic Publishing Страниц: 116 ISBN: 9783844332186
Описание
Traditionally, drugs were discovered by testing compounds synthesized in time consuming multi-step processes against a battery of in vivo biological screens. Promising compounds were then further studied in development, where their pharmaceutical properties, metabolism and potential toxicity were investigated. Here we present a study on herbal lead compounds and their potential binding affinity to the effectors molecules of major diseases like endometrial cancer. Clinical studies demonstrate a positive correlation between the extent of PDK1 and malignant progression of pre cancerous lesions in endometrial. Therefore, identification of effective, well-tolerated anti cancer inhibitor represents a rational chemo preventive strategy. This study has investigated the effects of naturally occurring compounds that inhibits the target. Our results reveal that these compounds use less energy to bind to the target and inhibit its activity than the commercial drugs used. Their high legend binding...
