Год выпуска: 2012 Автор: Hayder Al-Aubaidy Издательство: LAP Lambert Academic Publishing Страниц: 156 ISBN: 9783848419357
Описание
Type 2 diabetes is usually caused by a combination of pancreatic ?-cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterized by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. Many new pharmacological agents have been added to our armamentarium of treatments for DM in the last decade. The goal of all treatments is the same irrespective of the cause of the DM: namely, to normalize blood glucose. Incretin hormones (Glucagon like peptide, GLP and Glucose dependent insulinotropic peptide, GIP) are peptide hormones secreted by enteroendocrine cells that line the gastrointestinal (GIT) tract mainly from K & L cells of intestine, Following glucose or fat ingestion. These hormones are secreted in the blood and reach their various cellular targets. This study was done to: 1- Clarify the insulinotropic effect of the incretin hormones in the regulation of...
