Год выпуска: 2013 Автор: Belal Al-Husein,Somanath Shenoy and Anna Goc Издательство: Scholars' Press Страниц: 152 ISBN: 9783639518030
Описание
Prostate cancer is a leading cause of death in USA. Proper management of disease requires better understanding of mechanisms involved in cancer growth and proliferation. Statins were shown to have beneficial effects in cancers, as proven by the many clinical trials supporting the evidence. Our research studied simvastatin effects and molecular mechanisms affecting prostate cancer in vitro and in vivo. We showed that simvastatin affected proliferation, colony formation and migration, in both androgen-dependent and –independent human prostate cancer. In vivo effects were supportive with a reduction of tumor size in proper experimental models. Mechanisms of effect of simvastatin on cancer cell micrometastasis were also studied using ECIS, gene arrays, adhesion assays immunocytochemistry and western blotting and showed its effects on integrin and endothelial barrier. The effect of combining simvastatin with docetaxel was also studied and showed promising results. In conclusion, our...
