Design and Development of Carvedilol Phosphate Floating Microsphere Год выпуска: 2013Автор: Pranav Joshi,Mukesh Patel and Natavarlal PatelИздательство: LAP Lambert Academic PublishingСтраниц: 144ISBN: 9783659407635Описание Carvedilol has unique pharmacological profile. It blocks ?1, ?2, and ?1 receptors, used in the management of hypertension and as an adjunct to standard therapy in symptomatic heart failure and also produces vasodilation. In the present study, an attempt has been made to improve drug concentration in the stomach by preparing gastroretentive floating microsphere of carvedilol phosphate to maintain drug levels within a desired range, reduce dosing frequency, Improve patient compliance, improve dissolution and at the site of absorption.Drug molecules presenting no difficulties in their solubility and/or absorption problems are good candidates for oral controlled release formulations but Obstacle may arise for many drugs related to their solubility and/or absorption that may be overcome by formulating Gastroretentive systems which prolong the gastric retention time, improves solubility and hence improves bioavailability for drugs that are less soluble in a high pH environment.
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Евгения, 24.06 спасибо Юлия!!!я защитилась!!!!!задание нам дали заполнить на месте
