Год выпуска: 2013 Автор: Yash Paul Singla and Bhupender Singh Издательство: LAP Lambert Academic Publishing Страниц: 128 ISBN: 9783659445453
Описание
After the first decade of QSAR in mid 1970s, it was observed that relationship derived from a series of compounds investigated in isolated systems did not apply to in vivo situations. Hence, it was realized that ADME processes of a drug were important determinants, as these modulated the concentration-time profile of the drug substance at the drug receptor site. Indeed, lack of activity may not be due to low affinity of a drug for the receptor, but an inadequate concentration of the drug at these sites. The introduction of pharmacokinetic parameters permitted markedly better interpretation of the structure-activity correlation in physiological and biological terms. Development of QSPR amongst congeneric drug series not only saves considerable amount of time, money, animal life and involvement of “normally, healthy and drug-free human volunteers” required for conducting experimental pharmacokinetic studies, but also the expertise of pharmacokinetists and drug designers. Therefore, this...
