Год выпуска: 2012 Автор: Jitendra Vaghasiya and Krunal Mangukia Издательство: LAP Lambert Academic Publishing Страниц: 136 ISBN: 9783659264351
Описание
Objective: Present study was designed to investigate effect of gemfibrozil on I/R. Experimental: I/R in rats were induced by bilateral carotid artery occlusion (30 min) and followed by reperfusion (2 hrs). Results and Discussion: Gemfibrozil treated rats demonstrated significant reduction in infarct sizes (P < 0.05) when compared with I/R group of rats, suggested that gemfibrozil markedly attenuated I/R injury. Gemfibrozil treatment demonstrated a significant decreased in malondialdehyde (P < 0.01), and significant increased was observed in level of reduced glutathione (P < 0.01), superoxide dismutase (P < 0.05) and catalase (P < 0.01). Gemfibrozil treatment resulted significant increased in level of Na+-K+ ATPase (P < 0.05) and Mg+2 - ATPase (P < 0.01) and significant reduction of Ca+2 - ATPase (P ...
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