Development of in situ gel system for ocular drug delivery Год выпуска: 2012Автор: Himanshu GuptaИздательство: LAP Lambert Academic PublishingСтраниц: 128ISBN: 9783846582237Описание In situ gel-forming systems have drawn much attention of current researchers to overcome the poor bioavailability from the conventional eye drops. The present work described formulation and pharmacoscintigraphic evaluation of timolol-maleate-loaded chitosan/hydroxy propyl methyl cellulose(HPMC)-based polymer matrix for enhanced ocular retention. Chitosan and HPMC ratio was optimized and formulation was characterized for various in vitro parameters. The ocular retention was studied on New Zealand rabbits by gamma scintigraphy, which is a very simple and noninvasive technique. For scintigraphy study, the drug timolol maleate was radiolabeled 99mTc by direct labeling method. The labeling procedure was optimized to get maximum labeling efficiency(...
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Даниил Предыдущие 2 работы после вашего сопровождения показали, что у вас очень хорошо получается, так что я думаю - особых проблем не должно возникнуть. Напишите какая стоимость вас устраивает. О программе узнаю в ближайшее время.
