Год выпуска: 2012 Автор: Shabana Naz Shah Издательство: LAP Lambert Academic Publishing Страниц: 272 ISBN: 9783659125195
Описание
In this work, we investigated the “in vitro” interactions of prazosin with frequently prescribed and co-administered drugs in simulated human body environments and thus to infer about the combination therapy. The interacting drugs selected for interaction with prazosin are ACE-inhibitors (captopril, enalapril and lisinopril), calcium channel blockers (amlodipine, diltiazem and verapamil), H2 receptor antagonists (cimetidine, famotidine and ranitidine), NSAID’s (diclofenac sodium, flurbiprofen, mefenamic acid, meloxicam and naproxen), statins (atorvastatin, rosuvastatin and simvastatin) and hydrated salts of essential and trace elements (magnesium, calcium, chromium, manganese, ferric, cobalt, nickel, copper, zinc and cadmium). These interactions were conducted in simulated gastric juice (pH 1), simulating full stomach (pH 4), simulating blood pH (pH 7.4) and simulating intestinal pH (pH 9) using UV/visible spectrophotometric and reversed phase high performance liquid chromatography...
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