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Synthesized pyrazoline-carbothioamide as potent antitubercular agent


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Год выпуска: 2012
Автор: Dhrubo Jyoti Sen and Ravichandra G. Patel
Издательство: LAP Lambert Academic Publishing
Страниц: 68
ISBN: 9783659142932
Описание
 A brief introduction of M.tuberculosis has been summarized. Pharmacological importance and literature survey of pyrazolo derivatives has been summarized. All the synthesized compounds were characterized by UV, IR, Mass and 1H-NMRspectroscopy. All the newly synthesized compounds have been screened for antibacterial activity. Streptomycin was used as standard reference drug. Compound 57b has been found to have better antibacterial activity against gram+ve bacteria S.aureus and B.subtilis as compared to other synthesized compounds. Compounds 57b, 58a, 58b have been found to have better activity against gram-ve bacteria. None of the compound has been found to be equipotent with standard streptomycin. All the newly synthesized compounds were screened for antitubercular activity. Compound 57b has been found to be most potent among the series having MIC 6.25 µg/ml. Others synthesised compounds have been found to be active (having MIC 57a: 500 µg/ml, 57c: 25 µg/ml, 58a: 25 µg/ml, 58b: 62.5...

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