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Formulation and Characterization of Aceclofenac Microsphere


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Год выпуска: 2012
Автор: Sofiya Verma,Sandhya Chaurasia and Ashok Asati
Издательство: LAP Lambert Academic Publishing
Страниц: 96
ISBN: 9783659202322
Описание
 The purpose of this research was to prepare and characterize Aceclofenac microsphere of guar gum polymer for the application of inflammation. Method: - The microsphere were prepared by using emulsification method using starch cross-linked agent and coating was done by solvent evaporation method with the pH sensitive eudragit S-100 polymers. Result:-The prepared microsphere were white, free flowing and spherical in shape. The drug-loaded microsphere showed entrapment efficiency and drug release was extended upto 6 to 8 h. The infrared spectra, differential scanning calorimetry thermographs spectra all showed the stable character of both the drugs in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The stability study was conducted to conform the stability of prepared microsphere. In-vitro drug release study was performed in both simulated...

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