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Functionally Modified Alginate Particles for Oral Delivery of NSAIDs


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Год выпуска: 2014
Автор: SABYASACHI MAITI
Издательство: LAP Lambert Academic Publishing
Страниц: 96
ISBN: 9783659581199
Описание
 Calcium alginate microparticles alone are not suitable for sustained oral drug delivery applications. They rapidly disintegrate in weakly alkaline conditions of intestinal fluid and liberate their content. Herein, sodium alginate was chemically modified to circumvent this problem. The oxidation of the polymer was controlled such that oxidized alginate could form microparticles by ionic gelation with divalent Ca+2 ions. Oxidized polymer was characterized by measuring the aldehyde content, degree of oxidation and by FTIR spectroscopy. Spherical oxidized alginate particles were able to control the release of flurbiprofen in simulated gastrointestinal milieu for longer durations. The drug release correlated with the swelling nature of particles. In addition, ibuprofen-loaded Ca-alginate particles reinforced with cationic polyelectrolytes exhibited sustained drug release properties. The percentage drug release was very small in gastric fluid and thus could avoid gastric side effects...

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Zlodeyrip
Хочу поблагодарить вас за помощь которую вы мне оказывали. Диплом после вашего сопровождения защитил без особых проблем. Еще раз спасибо.