Год выпуска: 2011 Автор: Pradeep Kumar Издательство: LAP Lambert Academic Publishing Страниц: 140 ISBN: 9783843390316
Описание
The present research project deals with the design of cinnarizine loaded oral controlled release mucoadhesive interpenetrating polymer network hydrogel microspheres composed of chitosan and methylcellulose and optimization of various response parameters using response surface methodology. A detailed introduction, literature review and methodology has been provided for the readers to gain an insight into the theory and practice of design of experiments. The research work involved application of several core aspects of drug delivery incorporating polymer complexes, hydrogel networks, gastroretention, bioadhesion, absorption window related to weakly basic drugs, mathematical modeling of drug release kinetics, microencapsulation processes and various optimization and characterization techniques. The high degree of prognosis (due to low values of error) obtained using response surface methodology corroborates that a two-factor central composite design is quite efficient in optimizing drug...
