Design, Synthesis and Pharmacological Screening of 1,4-Diazepines Год выпуска: 2012Автор: Bhushan Bapat and Vishal ShahИздательство: LAP Lambert Academic PublishingСтраниц: 140ISBN: 9783848489367Описание Diazepines are pharmaceutically important compounds owing to their Central Nervous System Depressant activity. Among these 1,4-diazepines are regarded as privileged structures due to their clinical importance & commercial success. The immense work has been carried out on Diazepine nucleus. Investigators have followed variable routes for the synthesis, mostly 1,2-diamines are implemented as reagents using a catalyst that allows cyclization. Wide range of Biological activities exhibited by diazepines has attracted many workers to screen the analogues for all possible activities. Present book covers base catalyzed condensation reaction of 1, 2-diamines with carbonyl compounds, an efficient method for the synthesis of fused 1,4-diazepines. Synthesized compounds were characterized and screened for Cytotoxic, Anti-Microbial and Anti-convulsant Activities.
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