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Development of Sustained Release Tablets of Eplerenone


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Год выпуска: 2012
Автор: Sunil Reddy,Vinay Kumar Katakam and Madhusudan Rao Yamsani
Издательство: LAP Lambert Academic Publishing
Страниц: 68
ISBN: 9783659222887
Описание
 The objective of this work was to develop of a suitable SR tablet formulation of Eplerenone and to study the effect of polymers such as HPMC K4M, HPMC K15M, NaCMC, Guar gum, Xanthan gum and Karaya gum on drug release. Profile and to get an optimized formulation. Eplerenone binds to the mineralo corticoid receptor and blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). It has a half life of 4 hrs. When dose is missing it may cause nocturnal attack, so attention was made to develop the Sustained release tablets of Eplerenone. The purpose of controlled release systems is to maintain drug concentration in the blood or in target tissues at a desired value as long as possible. In other words, they are able to exert a control on the drug release rate and duration. In the market only IR tablets of Eplerenone were available which are costly. So there is a need to formulate SRMT of Eplerenone to reduce the cost and increase the patient...

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Надя, 21.02
Здравствуйте!!! Сегодня я защитила диплом на 4! спасибо вам тоже! теперь мы больше не будем доставать вас своими глупыми вопросами!!!! :) было приятно с вами работать! удачи вам!!!!