Год выпуска: 2011 Автор: Hayet Bensikaddour Издательство: LAP Lambert Academic Publishing Страниц: 180 ISBN: 9783846509333
Описание
Probing Fluoroquinolones-lipid interactions at the molecular level represents an important challenge in both membrane biophysics and pharmaceutical research. As the pharmacological target of these drugs is intracellular, they must pass across the bacterial membranes. Likewise, Fluoroquinolones enter eukaryotic cells, which imply their ability of interacting with lipids membranes. This book, therefore, characterize the effect of two closely related drugs ciprofloxacin CIP and moxifloxacin MXF on physicochemical properties of the major phospholipids that are mimicking the prokaryotic and the eukaryotic lipid membranes, respectively. Several models of lipid membranes and biophysical methods (Atomic force microscopy, Langmuir-Blodgett technique, as well as fluorescence, infra-red, nuclear magnetic resonance spectroscopies) are described. Our data suggest that the first step in the interaction of CIP with lipid membranes relates to its binding to the headgroups of phospholipids and that...
Спешу сказать Вам огромное бесконечное спасибо за помощь при написании диплома Финансовая стратегия предприятия. Я защитила диплом на отлично, все прекрасно. Еще раз спасибо, удачи в дальнейшей деятельности, с уважением и благодарностью, Оксана.