Год выпуска: 2010 Автор: Andrew M. Tan and Joel M. Levine Издательство: LAP Lambert Academic Publishing Страниц: 196 ISBN: 9783838383781
Описание
Damaged neurons in the CNS generally fail to regenerate after spinal cord injury (SCI), which may be due in part to the formation of the glial scar, a biochemical and physical barrier against axon growth. Here we report on evidence for 3 major conclusions. 1) Antibody-mediated blockade of the growth-inhibitory NG2 molecule found in glial scars is a viable strategy to promote sensory axon regeneration. 2) A combinatorial treatment approach that neutralizes extrinsic inhibition and stimulates intrinsic neuronal growth capacity is an important strategic consideration because this method can promote long-distance, anatomically correct axon regeneration. Accurate growth trajectory is a prerequisite for functional recovery. 3) After SCI and growth- promoting treatments, regenerated axons remain chronically demyelinated and exhibit pathophysiological function, similar to that observed in cases of multiple sclerosis. This suggests the need for further treatments designed to...
