Год выпуска: 2012 Автор: Avijit Dey,Md. Hamiduzzaman and Uttom Kumar Издательство: LAP Lambert Academic Publishing Страниц: 100 ISBN: 9783659232671
Описание
The four synthetic compounds named Ortho-amino aniline, 2-bromo propyl amine hydrobromide, 3-bromopopyl ammonium bromide and Benzimidazole-2-thiol were evaluated for their pharmacological activity. Evaluation of anti-oxidant activity was done by DPPH free radical scavenging activity. In this investigation, the compound ortho amino aniline showed the highest free radical scavenging activity with IC50 value 0.85?g/ml. At the same time Benzimadazole-2-Thiol also showed strong antioxidant potential having IC50 value 4.18?g/ml. The cyto-toxic activity was evaluated using Brine shrimp lethality bio-assay. Among the supplied compounds only ortho amino aniline and bennzimidazole-2-thiol showed mild cyto-toxic activity compared to the positive standard Vincristine sulfate. The analgesic activity was evaluated using acetic acid induced writhing method. The compounds Benzimidazole-2-thiol and 3-bromopopyl ammonium bromide at a dose of 50 mg/kg showed significant analgesic activity with 37.85%...
