Год выпуска: 2011 Автор: Simmi Kharb Издательство: LAP Lambert Academic Publishing Страниц: 124 ISBN: 9783846549025
Описание
The present study was conducted in sixty orthopedics patients who were divided into two groups, Group I with thirty patients of osteosarcoma and Group II with thirty patients with musculoskeletal pain.The present study indicated that serum folate and homocysteine levels were increased in osteosarcoma patients and decreased vitamin B12 and cholinesterase in osteosarcoma patients as compared to controls. Tumors are known to up regulate FRK, modulating the folate uptake in serum and increased homocysteine accumulation.Vitamin B12 diminishes osteoblastic activity and lowered serum vitamin B12 levels are possibly due to increased metabolic demand of the tumor. Raised homocysteine levels owing to contribution from rapidly proliferating cells resulted in decreased cholinesterase levels along with possible consumption of cholinesterase by osteoblasts in bone formation and tumorigenesis. Thus, cholinergic inhibitors, vitamin B12 supplementation, along with newer antifolate derivative and...