Год выпуска: 2012 Автор: Sameer Mohammad Издательство: LAP Lambert Academic Publishing Страниц: 92 ISBN: 9783659146497
Описание
Diabetes mellitus is one of the most serious healthcare concerns of 21st century and is characterized by deficiency or inaction of insulin. Exogenous insulin is quite helpful in ameliorating these conditions. But it fails to produce a well-controlled glycemic condition in association with variable dietary intake and physical activity. Episodes of severe hypoglycemia leading to deleterious cerebral impact are common during insulin administration. Thus there is a need to develop antidiabetic drugs that are effective, safe, produce a well-controlled normoglycemia and prevent the long-term complications. In searching for effective drugs in diabetes, vanadium emerged as an orally active insulin-mimetic agent. However, it was soon discovered that vanadium has several toxic effects on the animals and thus seriously undermined its antidiabetic potential. Efforts have been made to reduce the toxic effects of vanadate without compromising with its antidiabetic properties. The present...
